
Sunscreen in a Pill? Everything to Know About This New Sun Protection Trend
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In recent years, oral photoprotection, especially in the form of sunscreen pills, has emerged as an innovative strategy for promoting skin health. These systemic sunscreens, administered orally, provide a protective barrier against harmful UV radiation, thereby diminishing the likelihood of skin damage, premature ageing, and skin cancer.
In a discussion with, Dr. Rashmi Naldeega, a Consultant Dermatologist associated with Practo, highlighted several compounds with antioxidant properties that play a significant role in oral photoprotection. Some of these compounds include:
1. β-Carotene, a precursor to Vitamin A.
Renowned for its antioxidant capabilities, β-carotene mitigates free radicals generated by UV radiation, thereby bolstering the skin's defence against UV-induced redness and photoaging. Research indicates that it can alleviate sunburn and enhance the skin's resilience to UV exposure.
2. Antimalarial drugs such as chloroquine and hydroxychloroquine.
Primarily utilized for the treatment of malaria and autoimmune disorders, these medications also exhibit photoprotective effects. Clinical research has shown their efficacy in reducing UVB-induced erythema and inflammatory responses, further validating their function as systemic sunscreens.
3. Ascorbic Acid (Vitamin C).
This potent antioxidant aids in neutralizing free radicals and preventing collagen breakdown, which is essential for maintaining skin structure. Both topical and systemic applications of Vitamin C have been found to reduce photoaging, inhibit melanin production, and enhance skin texture.

4. α-Tocopherols (Vitamin E)
This serves to shield the skin from oxidative stress resulting from ultraviolet (UV) exposure. Research indicates that the combination of Vitamin E and Vitamin C enhances photoprotection, thereby diminishing UV-induced erythema and safeguarding against DNA damage.
5. Selenium
This trace mineral possesses antioxidant characteristics, effectively neutralizing free radicals and safeguarding cells from oxidative stress. Clinical research has demonstrated that selenium supplementation may lower the risk of skin cancer and slow the process of photoaging.
6. Green Tea Polyphenols
Notably, epigallocatechin gallate (EGCG) is recognized for its anti-inflammatory and antioxidant effects. These compounds help to mitigate UV-induced skin damage, reduce erythema, and prevent DNA mutations associated with skin cancer.
Dr. Rashmi Naldeega stated that the attractiveness of sunscreen pills is primarily due to their convenience. Unlike topical sunscreens, which necessitate frequent reapplication, oral supplements deliver consistent protection throughout the day, irrespective of exposure to sweat or water. This characteristic makes them particularly suitable for individuals who spend extended periods outdoors or participate in activities such as swimming or sports. Additionally, they serve as a beneficial alternative for those with sensitive skin who may suffer irritation from traditional topical sunscreens.
She further emphasized that while sunscreen pills provide internal protection, they do not prevent UV rays from reaching the skin. Consequently, it is essential to use them alongside conventional sunscreens and sun-safe practices. In summary, sunscreen pills signify a promising advancement in skin health, offering a practical and effective method for protecting the skin from within. As research progresses, they may become increasingly important in the realm of long-term UV protection.
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