Demi Moore was the favorite to take home the Best Actress award at the 2025 Academy Awards for her role in The Substance, but it was Mikey Madison who snagged the Oscar for her performance in Anora.

Madison made headlines as one of the youngest winners in the Best Actress category. Critics lauded her portrayal of a sex worker, and during her emotional acceptance speech, she honored the sex worker community and committed to providing more support.

On the other hand, cameras caught Moore's initial disappointment, but she quickly rallied to celebrate 25-year-old Madison. It's worth noting that Moore had already received accolades for her performance at various award shows, including the Golden Globes.

Lip Leader discusses how Demi Moore reacted

Nicola Hickling, a lip reader, chatted with the Daily Mail and mentioned that Moore appeared to say “nice” after the announcement, but she didn’t smile. According to Hickling, her body language suggested she was giving a slight nod to appear composed.

Moore was up for the Best Actress award alongside Cynthia Erivo, Mikey Madison, Fernanda Torres, and Karla Sofia Gascon.

Demi Moore's loss at the Oscars has led to some surprising reactions and a wave of memes

A lot of folks were excited about Madison's win, but some of Moore's fans were pretty bummed and took to X to share their feelings.

“My heart broke just like Demi Moore's when she didn’t hear her name. This was definitely her year,” one fan said.

“Demi Moore losing to Mikey Madison is like something out of The Substance,” ESPN writer Paolo Uggetti noted. That post racked up 126,000 likes and over 1.9 million views.

“Demi Moore lost. I’m done supporting the academy,” another fan chimed in.

“Honestly, I feel so bad. They hyped Demi all season just for her to lose right at the finish line. I’d be throwing a fit,” a fourth fan expressed.

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